Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate

Chemically Cross-Linked Poly(acrylic-co-vinylsulfonic) Acid Hydrogel for the Delivery of Isosorbide Mononitrate

We report synthesis, characterization, and drug release attributes of a series of novel pH-sensitive poly(acrylic-co-vinylsulfonic) acid hydrogels. These hydrogels were prepared by employing free radical polymerization using ethylene glycol dimethacrylate (EGDMA) and benzyl peroxide (BPO) as cross-linker and initiator, respectively. Effect of acrylic acid (AA), polyvinylsulfonic acid (PVSA), an...

Simultaneous measurement of plasma isosorbide dinitrate, isosorbide-2-mononitrate, and isosorbide-5-mononitrate by gas-liquid chromatography.

Isosorbide Mononitrate versus Misoprostol for Cervical Ripening

Objective: To compare the efficacy and safety of isosorbide mononitrate (IMN) versus misoprostol used to induce labour for overdue pregnancy. Setting: A prospective randomized clinical study conducted at AL-Elwiya Maternity Teaching Hospital in Baghdad from Jan. 2008 to Dec. 2008. Method: One hundred and fifty women with over due pregnancy (past date and posterm pregnancy) referred for inductio...

Preparation of Micro-Crystalline Cellulose-Reinforced Polyacrylic Acid Hydrogel and its Application in Paper/Polyacrylic Acid Composites

Paper/polyacrylic acid (PAA) composites were prepared using a microcrystalline cellulose (MCC)-reinforced PAA hydrogel. The MCC-reinforced PAA hydrogel was prepared by in-situ UV light-induced polymerization of acrylic acid in the presence of MCC. The experimental results showed that the presence of MCC improved the water absorption capacity of the resulting PAA hydrogel. The addition of 1 wt% ...

Development of pH Sensitive Nanoparticles for Intestinal Drug Delivery Using Chemically Modified Guar Gum Co-Polymer

The aim of the research work was to chemically modify guar gum(GG) as a pH sensitive co-polymer and formulating intestinal targeting ESO nanoparticles (NPs) using the synthesized co-polymer. Poly acrylamide-grafted-guar gum (PAAm-g-GG) co-polymer was synthesized by free radical polymerization. Chemical modification of PAAm-g-GG by alkaline hydrolysis results in formation of a pH-sensitive co-po...